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18 January 2016 Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study
Nicusor V. Iftimia, Gary Peterson, Ernest W. Chang, Gopi N. Maguluri, William J. Fox, Milind Rajadhyaksha
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Journal of Biomedical Optics, Vol. 21, Issue 1, 016006 (January 2016). https://doi.org/10.1117/1.JBO.21.1.016006
Abstract
We present a combined reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) approach, integrated within a single optical layout, for diagnosis of basal cell carcinomas (BCCs) and delineation of margins. While RCM imaging detects BCC presence (diagnoses) and its lateral spreading (margins) with measured resolution of ∼1  μm, OCT imaging delineates BCC depth spreading (margins) with resolution of ∼7  μm. When delineating margins in 20 specimens of superficial and nodular BCCs, depth could be reliably determined down to ∼600  μm, and agreement with histology was within about ±50  μm.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2016/$25.00 © 2016 SPIE
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Nicusor V. Iftimia, Gary Peterson, Ernest W. Chang, Gopi N. Maguluri, William J. Fox, and Milind Rajadhyaksha "Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study," Journal of Biomedical Optics 21(1), 016006 (18 January 2016). https://doi.org/10.1117/1.JBO.21.1.016006
Published: 18 January 2016
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Cited by 22 scholarly publications and 6 patents.
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KEYWORDS
Optical coherence tomography
Tumors
Reflectivity
Confocal microscopy
Tissues
Image resolution
Skin
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