Detection of melamine on fractals of unmodified gold nanoparticles by surface-enhanced Raman scattering

Pradip Kumar Roy; Yi-Fan Huang; Surojit Chattopadhyay

doi:10.1117/1.JBO.19.1.011002

10 June 2013 Detection of melamine on fractals of unmodified gold nanoparticles by surface-enhanced Raman scattering

Pradip Kumar Roy, Yi-Fan Huang, Surojit Chattopadhyay

Author Affiliations +

Funded by: National Science Council, Taiwan

Journal of Biomedical Optics, Vol. 19, Issue 1, 011002 (June 2013). https://doi.org/10.1117/1.JBO.19.1.011002

Abstract

A simple way of detecting melamine in raw milk is demonstrated via surface-enhanced Raman spectroscopy (SERS) using fractals of bare and nonfunctionalized ∼30 nm gold nanoparticles (AuNP) distributed on a solid support. The technique demonstrates the formation of AuNP fractals, from a random distribution, upon exposure to melamine, that enhance the Raman scattering cross-section to enable detection by SERS. The agglomeration, which is pronounced at higher melamine concentrations, is demonstrated directly through imaging, and the red-shift of the plasmon absorption peak of the AuNP fractal away from 530 nm by finite difference time domain (FDTD) calculations. The agglomeration results in a strong plasmon field, shown by FDTD, over the interparticle sites that enhances the Raman scattering cross-section of melamine and ensures unambiguous detection. Limit of detection of 100 ppb could be achieved reproducibly.

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Pradip Kumar Roy, Yi-Fan Huang, and Surojit Chattopadhyay "Detection of melamine on fractals of unmodified gold nanoparticles by surface-enhanced Raman scattering," Journal of Biomedical Optics 19(1), 011002 (10 June 2013). https://doi.org/10.1117/1.JBO.19.1.011002

Published: 10 June 2013

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KEYWORDS

Fractal analysis

Finite-difference time-domain method

Gold

Nanoparticles

Plasmons

Absorption

Silicon

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