Photoacoustic tomography through a whole adult human skull with a photon recycler

Liming Nie; Xin Cai; Konstantin I. Maslov; Alejandro Garcia-Uribe; Mark A. Anastasio; Lihong V. Wang

doi:10.1117/1.JBO.17.11.110506

2 November 2012 Photoacoustic tomography through a whole adult human skull with a photon recycler

Liming Nie, Xin Cai, Konstantin I. Maslov, Alejandro Garcia-Uribe, Mark A. Anastasio, Lihong V. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 11, 110506 (November 2012). https://doi.org/10.1117/1.JBO.17.11.110506

Abstract

Photoacoustic tomography (PAT) of the human brain is challenging due to the fact that the skull strongly absorbs and scatters light, and attenuates and distorts ultrasound as well. For the first time, we demonstrated the feasibility of PAT through a whole adult human skull. A photon recycler (PR) was built to increase light transmittance through the skull. Both a graphite target and a canine brain were imaged through the skull. Use of the PR was found to improve the photoacoustic signal-to-noise ratio by a factor of 2.4. In addition, subtraction of photoacoustic signals that arise from light absorption within the skull significantly improved the contrast of the target. Our results indicate that PAT can potentially be applied to in vivo human brain imaging.

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Liming Nie, Xin Cai, Konstantin I. Maslov, Alejandro Garcia-Uribe, Mark A. Anastasio, and Lihong V. Wang "Photoacoustic tomography through a whole adult human skull with a photon recycler," Journal of Biomedical Optics 17(11), 110506 (2 November 2012). https://doi.org/10.1117/1.JBO.17.11.110506

Published: 2 November 2012

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KEYWORDS

Skull

Acquisition tracking and pointing

Brain

Photoacoustic tomography

Ultrasonography

Neuroimaging

Signal to noise ratio

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