Potential of optical microangiography to monitor cerebral blood perfusion and vascular plasticity following traumatic brain injury in mice in vivo

Yali Jia; Nabil J. Alkayed M.D.; Ruikang K. Wang

doi:10.1117/1.3207121

1 July 2009 Potential of optical microangiography to monitor cerebral blood perfusion and vascular plasticity following traumatic brain injury in mice in vivo

Yali Jia, Nabil J. Alkayed M.D., Ruikang K. Wang

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Journal of Biomedical Optics, Vol. 14, Issue 4, 040505 (July 2009). https://doi.org/10.1117/1.3207121

Abstract

Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mouse brain upon traumatic brain injury (TBI), with the cranium left intact, for a period of two weeks on the same animal. We show the ability of OMAG to repeatedly image 3-D cerebral vasculatures during pre- and post-traumatic phases, and to visualize the changes of regulated CBF and the vascular plasticity after TBI. The results indicate the potential of OMAG to explore the mechanism involved in the rehabilitation of TBI.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Yali Jia, Nabil J. Alkayed M.D., and Ruikang K. Wang "Potential of optical microangiography to monitor cerebral blood perfusion and vascular plasticity following traumatic brain injury in mice in vivo," Journal of Biomedical Optics 14(4), 040505 (1 July 2009). https://doi.org/10.1117/1.3207121

Published: 1 July 2009

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