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1 November 2008 Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging
Mehmet B. Unlu, Yuting Lin, Ozlem Birgul, Orhan Nalcioglu, Gultekin Gulsen
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Journal of Biomedical Optics, Vol. 13, Issue 6, 060501 (November 2008). https://doi.org/10.1117/1.3041165
Abstract
We present simultaneous measurement of enhancement kinetics of an optical and a magnetic resonance (MR) contrast agent in a small animal breast tumor model (R3230 ac) using a combined MR-diffuse optical tomographic (MR-DOT) imaging system. A mixture of a small molecular-weight MR contrast agent gadolinium-diethylene-triamine-pentaacetic acid (Gd-DTPA) and a large molecular-weight optical contrast agent indocyanine green (ICG) was administered intravenously for multimodal dynamic imaging. Coregistration of optical and MR images was accomplished using agar-water–based markers. Using T2 and dynamic T1 weighted MR images, we divided the entire tumor into two regions of interest (ROI): a viable and a nonviable region. The absorption enhancements in the ROIs were calculated. An enhancement of the ICG was observed in the viable region. On the contrary, there was a lower enhancement in the nonviable region.
©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Mehmet B. Unlu, Yuting Lin, Ozlem Birgul, Orhan Nalcioglu, and Gultekin Gulsen "Simultaneous in vivo dynamic magnetic resonance-diffuse optical tomography for small animal imaging," Journal of Biomedical Optics 13(6), 060501 (1 November 2008). https://doi.org/10.1117/1.3041165
Published: 1 November 2008
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Cited by 15 scholarly publications.
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KEYWORDS
Magnetic resonance imaging
Tumors
Absorption
Magnetism
Imaging systems
Image enhancement
Breast cancer
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