Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case study

Natasha S. Shah; Jessica Gibbs; Dulcy E. Wolverton; Albert E. Cerussi; Nola M. Hylton; Bruce Jason Tromberg

doi:10.1117/1.2070147

1 September 2005 Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case study

Natasha S. Shah, Jessica Gibbs, Dulcy E. Wolverton, Albert E. Cerussi, Nola M. Hylton, Bruce Jason Tromberg

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Journal of Biomedical Optics, Vol. 10, Issue 5, 051503 (September 2005). https://doi.org/10.1117/1.2070147

Abstract

Monitoring tumor response to therapy can enable assessment of treatment efficacy, maximizing patient outcome and survival. We employ a noninvasive, handheld laser breast scanner (LBS) based on broadband diffuse optical spectroscopy (DOS) in conjunction with contrast-enhanced magnetic resonance imaging (cMRI) to assess tumor response to presurgical neoadjuvant chemotherapy. DOS and cMRI scans are performed after the first and fourth cycles of a doxorubicin/cyclophosphamide regimen in a patient with invasive ductal carcinoma. DOS measurements are used to quantify bulk tissue optical and physiological parameters, which are mapped to T₂- and T₁-weighted cMRI images. Initial DOS measurements show high tumor/normal contrast in total hemoglobin concentration (THC, 56±7 versus 27±4 µM) and water fraction (81.4±1% versus 24±3%) colocalized with regions of strongly enhancing T₂-wieghted and cMRI signals. After the fourth cycle of chemotherapy, we observe decreases in peak MRI contrast-enhancement values (37.6%) and apparent lesion volume (21.9 versus 13.7 cm³), which corresponds to physiological changes measured by DOS, including a 20 to 25% reduction in the spatial extent of the tumor and a 38.7% drop in mean total hemoglobin content (THC, 41.6 versus 23.4 µM). These data provide in vivo validation of the accuracy of broadband DOS and the sensitivity of optical methods to changes in tumor physiology.

©(2005) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Natasha S. Shah, Jessica Gibbs, Dulcy E. Wolverton, Albert E. Cerussi, Nola M. Hylton, and Bruce Jason Tromberg "Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case study," Journal of Biomedical Optics 10(5), 051503 (1 September 2005). https://doi.org/10.1117/1.2070147

Published: 1 September 2005

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