Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies

Guoqiang Yu; Turgut Durduran; Gwen Lech; Chao Zhou; Britton Chance; Emile R. Mohler M.D.; Arjun G. Yodh

doi:10.1117/1.1884603

1 March 2005 Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies

Guoqiang Yu, Turgut Durduran, Gwen Lech, Chao Zhou, Britton Chance, Emile R. Mohler M.D., Arjun G. Yodh

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Journal of Biomedical Optics, Vol. 10, Issue 2, 024027 (March 2005). https://doi.org/10.1117/1.1884603

Abstract

We have employed near-infrared optical methods to measure noninvasively the dynamics of muscle blood flow and oxygen saturation (S_tO₂) during cuff occlusion and plantar flexion exercise. Relative muscle oxygen consumption (rVO₂) was also computed from these data. Diffuse correlation spectroscopy provides information about blood flow, and diffuse reflectance spectroscopy provides information about blood oxygenation. Ten healthy subjects and one patient with peripheral arterial disease (PAD) were studied during 3-min arterial cuff occlusion of arm and leg, and during 1-min plantar flexion exercise. Signals from different layers (cutaneous tissues and muscles) during cuff occlusion were differentiated, revealing strong hemodynamic responses from muscle layers. During exercise in healthy legs, the observed ~4.7 fold increase in relative blood flow (rBF) was significantly lower than the corresponding increase in rVO₂ (~7 fold). The magnitudes of rBF and rVO₂ during exercise in the PAD patient were ~1/2 of the healthy controls, and the S_tO₂ recovery time was twice that of the controls. The hybrid instrument improves upon current technologies for measuring muscle responses by simultaneously measuring rBF and S_tO₂. The instrument thus provides a method for evaluation of microcirculation and muscle metabolism in patients with vascular diseases.

©(2005) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Guoqiang Yu, Turgut Durduran, Gwen Lech, Chao Zhou, Britton Chance, Emile R. Mohler M.D., and Arjun G. Yodh "Time-dependent blood flow and oxygenation in human skeletal muscles measured with noninvasive near-infrared diffuse optical spectroscopies," Journal of Biomedical Optics 10(2), 024027 (1 March 2005). https://doi.org/10.1117/1.1884603

Published: 1 March 2005

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