Infrared (IR) sounders, onboard satellites in low Earth orbit, are high spectral resolution interferometers capable of providing very accurate IR radiance measurements using thousands of channels. Though their temporal resolution is a relatively low 12 h, these data can be used to produce high vertical resolution temperature and humidity profiles. Imagers, often aboard satellites in geostationary Earth orbit, are radiometers providing high spatial and temporal resolution radiance measurements across a more limited number of bands, typically ∼10 to ∼20. Their data are used for monitoring Earth’s weather and climate. A data fusion method (developed and previously demonstrated at University of Wisconsin-Madison) is utilized to construct high vertical resolution, sounder-like temperature and humidity retrievals at imager high spatial and temporal resolution. Using the Crosstrack Infrared Sounder (CrIS) and Advanced Baseline Imager (ABI) data, comparison of concurrent and ∼50-min time-series fusion to radiosondes launched from February 2017 to March 2019 over the Department of Energy Atmospheric Radiation Measurement Southern Great Plains Site shows that the improved spatial and temporal resolution does not come at the expense of accuracy as compared with the sounder retrieval at native resolution.