Our work aimed to evaluate the use of visible–near-infrared (Vis–NIR) spectroscopy for predicting the production of leaf dry mass (LDM), as well as macro- and micronutrients contents of soybean leaves grown after application of limestone-mining coproducts. The treatments were arranged within a triple factorial scheme (6  ×  2  ×  2  +  2) and placed into pots in a greenhouse. We evaluated the following factors: type of input (limestone-mining coproducts), input particle size (filler and powder), and soil class (Arenosol and Ferralsol). After inputs incubation, the soybean was sown. Then, 42 days after sowing, we collected the foliar spectra, as well as leaves, for further analysis of the contents of macro- and micronutrients in leaves and production of LDM. We managed to adjust models at the stage of prediction with R²p  >  0.50 and RPD_p  >  1.50 for the variables LDM, P, K, Mg, S, and Zn, with emphasis on the first four, which presented R²p above 0.65. Therefore, we conclude that Vis–NIR spectroscopy has a potential for predicting LDM and the nutrients contents of soybean subjected to the application of limestone-mining coproducts, with advantages such as speed, low cost, and no use of reagents that are toxic to the environment.