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3 October 2024 Thermal membrane fluctuations determine the uptake of a trapped particle into giant unilamellar vesicles
Alexander Rohrbach, Yareni A. Ayala
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Proceedings Volume PC13112, Optical Trapping and Optical Micromanipulation XXI; PC131120Y (2024) https://doi.org/10.1117/12.3028171
Event: Nanoscience + Engineering, 2024, San Diego, California, United States
Abstract
Particle uptake is of huge interest in pharmacology and medicine, but a user-controlled uptake of particles into GUVs has been technically demanding. Here, we indent the membrane of differently composed GUVs with optically trapped particles until particle uptake. By continuous 1MHz back-focal-plane interferometric tracking and autocorrelating the particle’s positions within 30µs delays for different indentations, the fluctuations’ amplitude, the damping, the mean forces, and the energy profiles were obtained. The study demonstrates that soft matter can interact completely differently on different temporal and spatial frequency modes, which are excited by the environmental thermal noise.
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Alexander Rohrbach and Yareni A. Ayala "Thermal membrane fluctuations determine the uptake of a trapped particle into giant unilamellar vesicles", Proc. SPIE PC13112, Optical Trapping and Optical Micromanipulation XXI, PC131120Y (3 October 2024); https://doi.org/10.1117/12.3028171
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KEYWORDS
Particles
Autocorrelation
Interferometry
Life sciences
Medicine
Pharmacology
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