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3 October 2024 Single-molecule biophysical analysis with double nanohole optical tweezers
Reuven Gordon
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Proceedings Volume PC13112, Optical Trapping and Optical Micromanipulation XXI; PC1311208 (2024) https://doi.org/10.1117/12.3027161
Event: Nanoscience + Engineering, 2024, San Diego, California, United States
Abstract
For over a decade, our group has been trapping and analyzing single proteins using a double nanohole in a metal film. Our recent investigations have sought to improve the nanofabrication, including bottom-up mass-fabrication and a new fiber-based platform for microwell format investigation. We have also been developing approaches to modify the environment around a single trapped protein, for example, by integrating microfluidics and allowing for varying the background temperature. This allows for measuring properties like the optical size, hydrodynamic size, charge and thermophoretic properties a trapped protein. These new capabilities will be presented in this work.
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Reuven Gordon "Single-molecule biophysical analysis with double nanohole optical tweezers", Proc. SPIE PC13112, Optical Trapping and Optical Micromanipulation XXI, PC1311208 (3 October 2024); https://doi.org/10.1117/12.3027161
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KEYWORDS
Biological research
Optical tweezers
Proteins
Metals
Microfluidics
Nanofabrication
Thermography
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