Diamond quantum sensors for quantitative detection of iron load in ferritin proteins

David A. Simpson

doi:10.1117/12.3009004

13 March 2024 Diamond quantum sensors for quantitative detection of iron load in ferritin proteins

David A. Simpson

Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC128620A (2024) https://doi.org/10.1117/12.3009004
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The essential role of ferritin in iron homeostasis makes its study highly important for fundamental biochemistry research and clinical analysis of iron status, while the magnetic properties of its core mean that it holds interest for understanding magnetism in nanoscale condensed matter systems. Here we employ an emerging magnetic sensing technique using nitrogen-vacancy fluorescence defects in single crystal diamond and nanodiamonds, to quantify the magnetic properties of the iron core of ferritin as it is loaded. We observe anomalous magnetic behavior that can be explained using a theoretical model detailing a morphological change to the iron core occurring at relatively low iron loads. This model provides an L^(0.35±0.06) scaling of the uncompensated Fe spins, in agreement with previous theoretical predictions. The low detection limit (ferritin 2% loaded at a concentration of 7.5 ± 0.4 μg/mL) also makes this a promising method for precision applications where low analyte concentrations are unavoidable, such as in biological research or even clinical analysis.

Conference Presentation

Citation Download Citation

David A. Simpson "Diamond quantum sensors for quantitative detection of iron load in ferritin proteins", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC128620A (13 March 2024); https://doi.org/10.1117/12.3009004

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