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Quantifying the mechanical properties in thin layered structures poses a challenge due to the limited spatial resolution of the available mechanical analysis tools. Here, we propose a broadband (0.1 – 10 kHz) Rayleigh-wave optical coherence elastography technique and a bilayer-based inverse model to determine the elastic moduli of all three skin layers in vivo with high reliability. Our results show that 4 – 10 kHz, a previously unexplored frequency range, is critical to resolve the thin epidermis. Our proposed method is valuable for depth-resolved mechanical characterization of various layered materials and tissues.
Conference Presentation
(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
Xu Feng,Guo-Yang Li,Antoine Ramier,Amira Eltony, andSeok-Hyun Yun
"In vivo stiffness measurement of epidermis, dermis, and hypodermis using broadband Rayleigh-wave optical coherence elastography", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC1284402 (13 March 2024); https://doi.org/10.1117/12.2691018
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Xu Feng, Guo-Yang Li, Antoine Ramier, Amira Eltony, Seok-Hyun Yun, "In vivo stiffness measurement of epidermis, dermis, and hypodermis using broadband Rayleigh-wave optical coherence elastography," Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC1284402 (13 March 2024); https://doi.org/10.1117/12.2691018