A colonoscope-compatible photoacoustic and ultrasonic imaging catheter: initial clinical study in human subjects

Yaocai Huang; Xiaorui Peng; Laura Johnson; Xueding Wang; Peter Higgins; Guan Xu

doi:10.1117/12.3000638

13 March 2024 A colonoscope-compatible photoacoustic and ultrasonic imaging catheter: initial clinical study in human subjects

Yaocai Huang, Xiaorui Peng, Laura Johnson, Xueding Wang, Peter Higgins, Guan Xu

Author Affiliations +

Proceedings Volume PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024; PC1284207 (2024) https://doi.org/10.1117/12.3000638
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Crohn's Disease often leads to obstructing intestinal strictures caused by inflammation, fibrosis, and muscular hypertrophy. In this work, we developed a translational ultrasound/photoacoustic catheter probe that is compatible with standard colonoscopy procedures to differentiate normal, acute inflammation and fibrotic conditions in intestinal obstruction in rabbits. The prototype catheter probe consists of a 600-um core optical fiber for photoacoustic illumination and a miniaturized ultrasound array with 48 elements operating at 9.1 MHz for photoacoustic signal reception. A hydrostatic balloon covers the optical fiber and ultrasound array for acoustic coupling. Initial validation in rabbits was successful, and human subject evaluation is ongoing.

Conference Presentation

Citation Download Citation

Yaocai Huang, Xiaorui Peng, Laura Johnson, Xueding Wang, Peter Higgins, and Guan Xu "A colonoscope-compatible photoacoustic and ultrasonic imaging catheter: initial clinical study in human subjects", Proc. SPIE PC12842, Photons Plus Ultrasound: Imaging and Sensing 2024, PC1284207 (13 March 2024); https://doi.org/10.1117/12.3000638

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