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13 March 2024 Single-cell high precision ablation using nanosecond-pulsed thulium-doped fiber laser
Matthew D. Gerard, Hiroki Cook, James A. Read, Ibrahim Abughazaleh, Panuwat Srisamran, Sijing Liang, Qiang Fu, Richard O. C. Oreffo, David J. Richardson, Sumeet Mahajan, Lin Xu
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Proceedings Volume PC12840, Optical Interactions with Tissue and Cells XXXV; PC1284005 (2024) https://doi.org/10.1117/12.3000343
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
We demonstrate precise cellular laser ablation on SH-SY5Y and onion cells by using an advanced 1.95μm nanosecond-pulsed thulium-doped fibre laser (TDFL). The TDFL offers a high degree of control on pulse parameters, which enables good thermal and mechanical confinement during the laser ablation and results in a high precision of 30μm, with minimal carbonisation or collateral damage to surrounding cells. The realisation of precise cellular ablation from a TDFL will open up new applications in microsurgery for disease treatment, benefitting patients and researchers worldwide.
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Matthew D. Gerard, Hiroki Cook, James A. Read, Ibrahim Abughazaleh, Panuwat Srisamran, Sijing Liang, Qiang Fu, Richard O. C. Oreffo, David J. Richardson, Sumeet Mahajan, and Lin Xu "Single-cell high precision ablation using nanosecond-pulsed thulium-doped fiber laser", Proc. SPIE PC12840, Optical Interactions with Tissue and Cells XXXV, PC1284005 (13 March 2024); https://doi.org/10.1117/12.3000343
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KEYWORDS
Laser ablation
Fiber lasers
Cancer
Light absorption
Microsurgery
Neurosurgery
Oncology
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