Development of fluorescence tomography-guided radiotherapy for preclinical research

Xiangkun Xu; Yu-Pei Tseng; Zhishen Tong; Luke Hardy; Hamid Dehghani; Iulian Iordachita; John Wong; Ken Kang-Hsin Wang

doi:10.1117/12.3001694

13 March 2024 Development of fluorescence tomography-guided radiotherapy for preclinical research

Xiangkun Xu, Yu-Pei Tseng, Zhishen Tong, Luke Hardy, Hamid Dehghani, Iulian Iordachita, John Wong, Ken Kang-Hsin Wang

Proceedings Volume PC12834, Multimodal Biomedical Imaging XIX; PC128340E (2024) https://doi.org/10.1117/12.3001694
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

To enhance the functional image-guided capabilities in preclinical radiotherapy research, we developed fluorescence tomography (FT) and integrated it with a commercial bioluminescence tomography (BLT) system for small animal irradiators. We devised a novel method to achieve submillimeter accuracy in mapping the excitation sources and fluorescence data to the imaged animal surface. We expect to achieve approximately 1 mm accuracy in 3D target localization for in vivo tumor model. The multi-model FT/BLT-guided system will provide advanced image-guided capabilities to enhance preclinical radiotherapy research, particularly in cases where radiation is combined with other systemic treatments, thus expanding its applications beyond local therapy.

Conference Presentation

Citation Download Citation

Xiangkun Xu, Yu-Pei Tseng, Zhishen Tong, Luke Hardy, Hamid Dehghani, Iulian Iordachita, John Wong, and Ken Kang-Hsin Wang "Development of fluorescence tomography-guided radiotherapy for preclinical research", Proc. SPIE PC12834, Multimodal Biomedical Imaging XIX, PC128340E (13 March 2024); https://doi.org/10.1117/12.3001694

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