Validation of total hemoglobin concentrations in healthy human subjects by visible-light spectroscopic optical coherence tomography

Carlos Cuartas-Vélez; Isabella Gómez Gallego; Nienke Bosschaart

doi:10.1117/12.3001549

13 March 2024 Validation of total hemoglobin concentrations in healthy human subjects by visible-light spectroscopic optical coherence tomography

Carlos Cuartas-Vélez, Isabella Gómez Gallego, Nienke Bosschaart

Author Affiliations +

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC128301V (2024) https://doi.org/10.1117/12.3001549
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Quantification of total hemoglobin concentrations [tHb] is imperative to determine blood-related diseases such as anemia. In this work, we validate [tHb] estimates by visible-light spectroscopic optical coherence tomography (vis-sOCT) with the gold standard, intravenous blood sample analysis from a commercial avoximeter. We recruited a group of 27 volunteers and retrieved [tHb] with vis-sOCT data from the microcirculation in the skin of the left posterior forearm. Expected [tHb] were obtained from blood sample analysis by a commercial analyzer. We compare the [tHb] estimated by vis-sOCT with the expected [tHb]. Additionally, the effect of multiple factors of influence such as gender, skin tone, and epidermal thickness is investigated.

Conference Presentation

Citation Download Citation

Carlos Cuartas-Vélez, Isabella Gómez Gallego, and Nienke Bosschaart "Validation of total hemoglobin concentrations in healthy human subjects by visible-light spectroscopic optical coherence tomography", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128301V (13 March 2024); https://doi.org/10.1117/12.3001549

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