Towards non-contact and real-time large field-of-view single-band Raman spectroscopy imaging in brain cancer surgery

Frédéric Leblond; Sandryne David; Samaneh Pahlavani; Nassim Ksantini; Frédérick Dallaire; Guillaume Sheehy; Costas Hadjapanayis; Kevin Petrecca; Brian C. Wilson

doi:10.1117/12.3001248

13 March 2024 Towards non-contact and real-time large field-of-view single-band Raman spectroscopy imaging in brain cancer surgery

Frédéric Leblond, Sandryne David, Samaneh Pahlavani, Nassim Ksantini, Frédérick Dallaire, Guillaume Sheehy, Costas Hadjapanayis, Kevin Petrecca, Brian C. Wilson

Author Affiliations +

Proceedings Volume PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X; PC1282505 (2024) https://doi.org/10.1117/12.3001248
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

This research introduces a new approach based on Raman spectroscopy for quickly and effectively detecting brain tumors at a macroscopic scale, making it suitable for intra-operative use. By focusing on a specific vibrational band at 1440 cm-1 as a cancer biomarker, this method will enable rapid imaging of a field of view spanning several centimeters in approximately 5 seconds. The results of this study demonstrated high sensitivity/specificity for meningioma (97%/95%), brain metastases (95%/91%), and glioblastoma (78%/84%). The performance of this developed imaging system was compared to a custom hyperspectral line-scanning Raman system as the gold standard.

Conference Presentation

Citation Download Citation

Frédéric Leblond, Sandryne David, Samaneh Pahlavani, Nassim Ksantini, Frédérick Dallaire, Guillaume Sheehy, Costas Hadjapanayis, Kevin Petrecca, and Brian C. Wilson "Towards non-contact and real-time large field-of-view single-band Raman spectroscopy imaging in brain cancer surgery", Proc. SPIE PC12825, Molecular-Guided Surgery: Molecules, Devices, and Applications X, PC1282505 (13 March 2024); https://doi.org/10.1117/12.3001248

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