Daily trends in cone photoreceptor reflectivity heterogeneity investigated with adaptive optics

Arman Athwal; Danuta Sampson; Shruti Chandra; Sobha Sivaprasad; Glen Jeffery; Marinko V. Sarunic

doi:10.1117/12.3003697

13 March 2024 Daily trends in cone photoreceptor reflectivity heterogeneity investigated with adaptive optics

Arman Athwal, Danuta Sampson, Shruti Chandra, Sobha Sivaprasad, Glen Jeffery, Marinko V. Sarunic

Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC128241N (2024) https://doi.org/10.1117/12.3003697
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

This study investigated the daily trends in the spatial and temporal heterogeneity of cone photoreceptor reflectivity. Cones contain a high density of mitochondria in their inner segments, and metabolic rates are thought to vary on a daily cycle. To test this, both eyes from ten healthy human volunteers were imaged multiple times per day (9:00am, 11:00am, 1:00pm) with an adaptive optics flood illumination camera before and after stimulation of one eye with a uniform red light, the wavelength of which is thought to promote mitochondrial metabolism. Results indicate strong statistical relationships between time of day and cone reflectivity and spatial heterogeneity. Irrespective of red light stimulus, cone reflectivity decreased by an average of 3.08 ± 3.22% in the afternoon compared to morning, and spatial heterogeneity decreased by 6.43 ± 4.51%.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Arman Athwal, Danuta Sampson, Shruti Chandra, Sobha Sivaprasad, Glen Jeffery, and Marinko V. Sarunic "Daily trends in cone photoreceptor reflectivity heterogeneity investigated with adaptive optics", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC128241N (13 March 2024); https://doi.org/10.1117/12.3003697

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