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The most clinically compatible PAT configuration usually employs a linear ultrasound array, which often has a limited detection view and poor image fidelity. Exogenous contrast agents such as nanoparticles can be employed but lacks clinical translation potential. We have developed a new methodology by using clinically-approved microbubble as virtual point sources that strongly scatter the local pressure waves from surround hemoglobin, preserving PAT’s functional capability and clinical translation potential. We can overcome the limited-detection-view problem and achieve high-fidelity functional PAT in deep tissue. We have investigated the working principle and demonstrated proof-of-concept applications using simulations, phantoms, and in vivo small-animal studies.
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