Evaluation of electrical characteristics of bovine eyes for detection of uveal melanoma

Yaibhav B. Yadav; Alison Skalet; Mohammad J. Moghimi

doi:10.1117/12.2650858

6 March 2023 Evaluation of electrical characteristics of bovine eyes for detection of uveal melanoma

Yaibhav B. Yadav, Alison Skalet, Mohammad J. Moghimi

Proceedings Volume PC12374, Microfluidics, BioMEMS, and Medical Microsystems XXI; PC1237409 (2023) https://doi.org/10.1117/12.2650858
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Uveal melanoma is the most common intraocular cancer in adults and may cause vision loss as well as death due to distant metastases. Early detection of tumors is critical for vision preservation and may reduce mortality. Many patients with uveal melanoma do not develop symptoms in early stages of disease when tumors are small. Diagnosis requires examination of the eye using specialized equipment and may require advanced imaging techniques. Here, we studied the electrical properties of eyes to investigate a novel, easy-to-use method for detecting uveal melanoma. We used finite element analysis to study the electrical impedance and current density in bovine eyes. We also measured the impedance and current flow in the preserved bovine eyes using a high precision impedance analyzer. Our experimental data show that a 6 mm-diameter added tissue was detected inside a 30-mm diameter eyeball by impedance analyzer, paving the way toward detection of solid tumors in eyeballs.

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Citation Download Citation

Yaibhav B. Yadav, Alison Skalet, and Mohammad J. Moghimi "Evaluation of electrical characteristics of bovine eyes for detection of uveal melanoma", Proc. SPIE PC12374, Microfluidics, BioMEMS, and Medical Microsystems XXI, PC1237409 (6 March 2023); https://doi.org/10.1117/12.2650858

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KEYWORDS

Eye

Melanoma

Tumors

Cornea

Retina

Finite element methods

Solids

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