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6 March 2023 Lossy mode resonance-based optical-fibre sensor for SARS-CoV-2 detection
Kamil Kosiel, Joanna Jankowska-Śliwińska, Anna Szerling, Piotr Polak, Krzysztof Grabczewski, Maciej Kozubal, Karina Wojciechowska, Laura Stanco, Renata Kruszka, Ryszard Buczyński, Grzegorz Stępniewski, Dariusz Pysz, Michal O. Szymanski, Krzysztof Domański, Piotr Prokaryn, Konrad Dudziński
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Proceedings Volume PC12372, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII; PC1237208 (2023) https://doi.org/10.1117/12.2649173
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
We present a fibre optic biosensor for SARS-CoV-2 detection based on the lossy-mode-resonance (LMR) [6] effect, generated in a single-mode fibre with a thinned cladding and coated by thin-film dielectric with appropriately selected optical properties and thickness. The detection of selected viral structural proteins in the tested sample is ensured by specific bioreceptors. As a result of the interaction with the SARS-CoV-2 antigen, optical response in the short-wave-IR range is observed, and the detection limit does not exceed 1.3*10^2 copies/ml, when converted to the viral load concentration - sufficiently for virus detection even in the first days after infection.
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Kamil Kosiel, Joanna Jankowska-Śliwińska, Anna Szerling, Piotr Polak, Krzysztof Grabczewski, Maciej Kozubal, Karina Wojciechowska, Laura Stanco, Renata Kruszka, Ryszard Buczyński, Grzegorz Stępniewski, Dariusz Pysz, Michal O. Szymanski, Krzysztof Domański, Piotr Prokaryn, and Konrad Dudziński "Lossy mode resonance-based optical-fibre sensor for SARS-CoV-2 detection", Proc. SPIE PC12372, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII, PC1237208 (6 March 2023); https://doi.org/10.1117/12.2649173
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KEYWORDS
Sensors
Control systems
Microfluidics
Optical properties
Proteins
Short wave infrared radiation
Single mode fibers
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