Alteration of corneal epithelial-stromal interactions by NIR-femtosecond laser irradiation for therapeutic modulation of wound healing processes

Mikhail Fomovsky; Jiashuai Fan; Sinisa Vukelic

doi:10.1117/12.2647310

17 March 2023 Alteration of corneal epithelial-stromal interactions by NIR-femtosecond laser irradiation for therapeutic modulation of wound healing processes

Mikhail Fomovsky, Jiashuai Fan, Sinisa Vukelic

Author Affiliations +

Proceedings Volume PC12362, Mechanisms of Photobiomodulation Therapy XVII; PC1236205 (2023) https://doi.org/10.1117/12.2647310
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

This study proposes a treatment to improve post-trauma corneal wound healing through application of short-lived bursts of reactive oxygen species obtained via ionization of interstitial water by an ultrafast laser-induced low-density plasma. Laser irradiation has been restricted to intensities below the optical breakdown threshold and applied onto interleukin-1β (IL-1β) in aqueous solution, and rabbit corneas in vivo with epithelium removed to simulate external trauma. Quantitative ELISA assays have shown lowered binding affinity of the laser-treated IL-1β to receptor IL1-R1 in aqueous solutions. Laser application on epithelium removed in-vivo rabbit corneas resulted in a preservation of stromal keratocytes and accelerated healing.

Conference Presentation

Citation Download Citation

Mikhail Fomovsky, Jiashuai Fan, and Sinisa Vukelic "Alteration of corneal epithelial-stromal interactions by NIR-femtosecond laser irradiation for therapeutic modulation of wound healing processes", Proc. SPIE PC12362, Mechanisms of Photobiomodulation Therapy XVII, PC1236205 (17 March 2023); https://doi.org/10.1117/12.2647310

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