CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume PC11973 > Article
Presentation
2 March 2022 Quantifying pharmacodynamics in a mouse inflammation model via CARS and SRS imaging paired with machine learning analysis
Daniel Greenfield, Conor L. Evans
Author Affiliations +
Proceedings Volume PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022; PC1197308 (2022) https://doi.org/10.1117/12.2608687
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
The onset and progression of dermal inflammation are easy to diagnose, but challenging to quantify, stage, and measure. CARS and SRS imaging are modalities capable of providing insight into the dynamics of structural and drug/fluid concentration changes throughout a time course of tissue imaging. This work displays two main avenues of exploration using dermatitis-induced mouse models. First, we track inflammation development and resolution over a four-day time course, capturing CARS and SRS image data at multiple time points to use in a machine learning (ML) based approach trained to classify the extent of inflammation in the provided images. Second, we treat mice with anti-inflammatory agents to determine whether these agents truly help with inflammation resolution, using our ML-based approach trained on structural and concentration rich images as a proxy for the pharmacodynamic response. We additionally use ML interpretability methods to aid in the justification of our results.
Conference Presentation
© (2022) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Daniel Greenfield and Conor L. Evans "Quantifying pharmacodynamics in a mouse inflammation model via CARS and SRS imaging paired with machine learning analysis", Proc. SPIE PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022, PC1197308 (2 March 2022); https://doi.org/10.1117/12.2608687
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Ear
Inflammation
CARS tomography
Machine learning
Convolutional neural networks
Diagnostics
Mouse models
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top