Optogenetic investigation of mouse embryonic cardiogenesis with continuous-wave light stimulation

Deirdre M. Scully; Andrew L Lopez III; Irina V. Larina

doi:10.1117/12.2609124

7 March 2022 Optogenetic investigation of mouse embryonic cardiogenesis with continuous-wave light stimulation

Deirdre M. Scully, Andrew L Lopez III, Irina V. Larina

Author Affiliations +

Proceedings Volume PC11936, Diagnostic and Therapeutic Applications of Light in Cardiology 2022; PC119360C (2022) https://doi.org/10.1117/12.2609124
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The mouse embryo is an established model for investigation of regulatory mechanisms controlling cardiac development and congenital heart defects in humans. Optogenetics, originally developed for neuroscience research, has recently been shown to control embryonic mouse heartbeat with pulsed light in a range of stimulation frequencies. The aim of this study was to explore continuous wave optogenetic light stimulation for activation of contractions through regions of the heart. This study suggests a potential to use continuous wave optogenetic stimulation for quick identification and investigation of developmental origin of cardiac cell populations in addition to previously established manipulation of embryo cardiodynamics.

Conference Presentation

Citation Download Citation

Deirdre M. Scully, Andrew L Lopez III, and Irina V. Larina "Optogenetic investigation of mouse embryonic cardiogenesis with continuous-wave light stimulation", Proc. SPIE PC11936, Diagnostic and Therapeutic Applications of Light in Cardiology 2022, PC119360C (7 March 2022); https://doi.org/10.1117/12.2609124

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