Non-invasive thermal IR detection of breast tumor development in vivo

Jason R. Case; Madison A. Young; D. Dréau; Susan R. Trammell

doi:10.1117/12.2081398

18 March 2015 Non-invasive thermal IR detection of breast tumor development in vivo

Jason R. Case, Madison A. Young, D. Dréau, Susan R. Trammell

Author Affiliations +

Proceedings Volume 9412, Medical Imaging 2015: Physics of Medical Imaging; 94124Q (2015) https://doi.org/10.1117/12.2081398
Event: SPIE Medical Imaging, 2015, Orlando, Florida, United States

Abstract

Lumpectomy coupled with radiation therapy and/or chemotherapy comprises the treatment of breast cancer for many patients. We are developing an enhanced thermal IR imaging technique that can be used in real-time to guide tissue excision during a lumpectomy. This novel enhanced thermal imaging method is a combination of IR imaging (8- 10 μm) and selective heating of blood (~0.5 °C) relative to surrounding water-rich tissue using LED sources at low powers. Post-acquisition processing of these images highlights temporal changes in temperature and is sensitive to the presence of vascular structures. In this study, fluorescent and enhanced thermal imaging modalities were used to estimate breast cancer tumor volumes as a function of time in 19 murine subjects over a 30-day study period. Tumor volumes calculated from fluorescent imaging follow an exponential growth curve for the first 22 days of the study. Cell necrosis affected the tumor volume estimates based on the fluorescent images after Day 22. The tumor volumes estimated from enhanced thermal imaging show exponential growth over the entire study period. A strong correlation was found between tumor volumes estimated using fluorescent imaging and the enhanced IR images, indicating that enhanced thermal imaging is capable monitoring tumor growth. Further, the enhanced IR images reveal a corona of bright emission along the edges of the tumor masses. This novel IR technique could be used to estimate tumor margins in real-time during surgical procedures.

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Jason R. Case, Madison A. Young, D. Dréau, and Susan R. Trammell "Non-invasive thermal IR detection of breast tumor development in vivo", Proc. SPIE 9412, Medical Imaging 2015: Physics of Medical Imaging, 94124Q (18 March 2015); https://doi.org/10.1117/12.2081398

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KEYWORDS

Tumors

Thermography

Infrared imaging

Tissues

Breast cancer

Light emitting diodes

Blood

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