Application of laser speckle contrast image in the evaluation of arthritis animal model

Taeyoon Son; Won Hyuk Jang; Jihoon Park; Hyung-Ju Yoon; Jeon Lee; Wan-Uk Kim; Byungjo Jung

doi:10.1117/12.2004013

8 March 2013 Application of laser speckle contrast image in the evaluation of arthritis animal model

Taeyoon Son, Won Hyuk Jang, Jihoon Park, Hyung-Ju Yoon, Jeon Lee, Wan-Uk Kim, Byungjo Jung

Author Affiliations +

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 85650Q (2013) https://doi.org/10.1117/12.2004013
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Arthritis is a chronic inflammatory disease that induces potentially damaging and commonly disabling. Various imaging modalities have been used for the evaluation of arthritis. This study aimed to investigate the feasibility of laser speckle contrast image (LSCI) in the evaluation of the severity and early stage of arthritis in animal model. Arthritis was induced on mouse foot and evaluated by a trained expert and the LSCI. The arthritis severity was quantitatively evaluated by speckle index (SI) computed from LSCI. In visual inspection by an expert, it was difficult to evaluate the arthritis because there was no noticeable different between control mouse group (CMG) and arthritis mouse group (AMG) in erythema. However, arthritis was easily evaluated by significant SI different between the CMG and AMG. In addition, the LSCI also successfully evaluated the early stage of arthritis, presenting different SI distribution depending on lesion.

Citation Download Citation

Taeyoon Son, Won Hyuk Jang, Jihoon Park, Hyung-Ju Yoon, Jeon Lee, Wan-Uk Kim, and Byungjo Jung "Application of laser speckle contrast image in the evaluation of arthritis animal model", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85650Q (8 March 2013); https://doi.org/10.1117/12.2004013

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KEYWORDS

Laser speckle contrast imaging

Speckle

Animal model studies

Blood

Optical inspection

CCD cameras

Image analysis

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