Photosensitizer fluorescence emission during photodynamic therapy applied to dermatological diseases

I. Salas-García; F. Fanjul-Vélez; N. Ortega-Quijano; J. L. Arce-Diego

doi:10.1117/12.912065

11 October 2011 Photosensitizer fluorescence emission during photodynamic therapy applied to dermatological diseases

I. Salas-García, F. Fanjul-Vélez, N. Ortega-Quijano, J. L. Arce-Diego

Proceedings Volume 8306, Photonics, Devices, and Systems V; 83060K (2011) https://doi.org/10.1117/12.912065
Event: Photonics Prague 2011, 2011, Prague, Czech Republic

Abstract

We present a first approach to predict the photosensitizer fluorescence dependence with depth during the Photodynamic Therapy applied to a skin disease commonly treated in the dermatological clinical practice. The obtained results permit us to know the photosensitizer temporal fluorescence evolution in different points of the tumor sample during the photochemical reactions involved in PDT with a predictive purpose related to the treatment evolution. The model presented also takes into account the distribution of a topical photosensitizer, the propagation of light in a biological media and the subsequent photochemical interactions between light and tissue. This implies that different parameters related with the photosensitizer distribution or the optical source characteristics could be adjusted to provide a specific treatment to a particular pathology.

Citation Download Citation

I. Salas-García, F. Fanjul-Vélez, N. Ortega-Quijano, and J. L. Arce-Diego "Photosensitizer fluorescence emission during photodynamic therapy applied to dermatological diseases", Proc. SPIE 8306, Photonics, Devices, and Systems V, 83060K (11 October 2011); https://doi.org/10.1117/12.912065

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