Magnetization spectroscopy of biocompatible magnetite (Fe3O4) nanoparticles for MPI

R. Matthew Ferguson; Amit P. Khandhar; Kannan M. Krishnan

doi:10.1117/12.878321

9 March 2011 Magnetization spectroscopy of biocompatible magnetite (Fe₃O₄) nanoparticles for MPI

R. Matthew Ferguson, Amit P. Khandhar, Kannan M. Krishnan

Proceedings Volume 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging; 79650W (2011) https://doi.org/10.1117/12.878321
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

We report the use of a nanoparticle magnetization spectrometer to measure the suitability of magnetite nanoparticles for magnetic particle imaging (MPI). The spectrometer, which measures the strength of harmonics in the magnetization of magnetic nanoparticles, produces a driving field at 25 kHz and measures up to 40 harmonics (1Mhz bandwidth). Large, uniform, single-core magnetite particles with diameter ranging from 17 to 22 nm were synthesized for this work and their magnetization spectra were compared with a commercially available option, Resovist. The driving field amplitude was varied and spectra were acquired for field amplitudes ranging from 9.7 to 18.6 mTμ₀^-1. Compared with Resovist, synthesized particles showed increased harmonic power over the full measured frequency range at each driving field.

Citation Download Citation

R. Matthew Ferguson, Amit P. Khandhar, and Kannan M. Krishnan "Magnetization spectroscopy of biocompatible magnetite (Fe₃O₄) nanoparticles for MPI", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650W (9 March 2011); https://doi.org/10.1117/12.878321

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