Assessment of variability in cerebral vasculature for neuro-anatomical surgery planning in rodent brain

J. R. Rangarajan; K. Van Kuyck; U. Himmelreich; B. Nuttin; F. Maes; P. Suetens

doi:10.1117/12.878154

9 March 2011 Assessment of variability in cerebral vasculature for neuro-anatomical surgery planning in rodent brain

J. R. Rangarajan, K. Van Kuyck, U. Himmelreich, B. Nuttin, F. Maes, P. Suetens

Proceedings Volume 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging; 79650Q (2011) https://doi.org/10.1117/12.878154
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

Clinical and pre-clinical studies show that deep brain stimulation (DBS) of targeted brain regions by neurosurgical techniques ameliorate psychiatric disorder such as anorexia nervosa. Neurosurgical interventions in preclinical rodent brain are mostly accomplished manually with a 2D atlas. Considering both the large number of animals subjected to stereotactic surgical experiments and the associated imaging cost, feasibility of sophisticated pre-operative imaging based surgical path planning and/or robotic guidance is limited. Here, we spatially normalize vasculature information and assess the intra-strain variability in cerebral vasculature for a neurosurgery planning. By co-registering and subsequently building a probabilistic vasculature template in a standard space, we evaluate the risk of a user defined electrode trajectory damaging a blood vessel on its path. The use of such a method may not only be confined to DBS therapy in small animals, but also could be readily applicable to a wide range of stereotactic small animal surgeries like targeted injection of contrast agents and cell labeling applications.

Citation Download Citation

J. R. Rangarajan, K. Van Kuyck, U. Himmelreich, B. Nuttin, F. Maes, and P. Suetens "Assessment of variability in cerebral vasculature for neuro-anatomical surgery planning in rodent brain", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650Q (9 March 2011); https://doi.org/10.1117/12.878154

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