The use of optical polarimetry as a noninvasive in vivo physiological glucose monitor

Anthony J. Webb; Brent D. Cameron

doi:10.1117/12.875230

10 February 2011 The use of optical polarimetry as a noninvasive in vivo physiological glucose monitor

Anthony J. Webb, Brent D. Cameron

Proceedings Volume 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III; 79060E (2011) https://doi.org/10.1117/12.875230
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

There is a need to effectively and accurately monitor physiological glucose levels in individuals afflicted with diabetes mellitus. One promising noninvasive technique involves the use of optical polarimetry, in which the eye is commonly used as the sensing location. Since glucose is a chiral molecule, it has the ability to rotate plane polarized light by an amount that is proportional to glucose concentration. It has also been shown that glucose levels in the aqueous humor of the eye correlate well to those of blood. Therefore, we will report on an in vivo study that is conducted using a New Zealand White (NZW) rabbit model in conjunction with a custom developed Faradaybased optical polarimeter with sub-millidegree resolution. All animals used in this investigation were anesthetized with isoflurane and an insulin/dextrose protocol was used to control blood glucose concentration. A polarized laser light (632.8nm HeNe) signal was coupled through the anterior chamber of the eye using a custom designed ocular apparatus. System calibration was performed through measurement of the detected optical polarimetric signal and corresponding discrete blood glucose measurements taken with a handheld glucometer. Reference blood glucose samples were also measured using a YSI 2300+ glucose analyzer. The study results show that physiological glucose can be predicted with error levels on the order of 15%.

Citation Download Citation

Anthony J. Webb and Brent D. Cameron "The use of optical polarimetry as a noninvasive in vivo physiological glucose monitor", Proc. SPIE 7906, Optical Diagnostics and Sensing XI: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue III, 79060E (10 February 2011); https://doi.org/10.1117/12.875230

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available