Transcranial laser therapy alters amyloid precursor protein processing and improves mitochondrial function in a mouse model of Alzheimer's disease

Thomas McCarthy; Jin Yu; Salim El-Amouri; Sebastiano Gattoni-Celli; Steve Richieri; Luis De Taboada; Jackson Streeter; Mark S. Kindy

doi:10.1117/12.877028

17 February 2011 Transcranial laser therapy alters amyloid precursor protein processing and improves mitochondrial function in a mouse model of Alzheimer's disease

Thomas McCarthy, Jin Yu, Salim El-Amouri, Sebastiano Gattoni-Celli, Steve Richieri, Luis De Taboada, Jackson Streeter, Mark S. Kindy

Author Affiliations +

Proceedings Volume 7887, Mechanisms for Low-Light Therapy VI; 78870K (2011) https://doi.org/10.1117/12.877028
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Transcranial laser therapy (TLT) using a near-infrared energy laser system was tested in the 2x Tg amyloid precursor protein (APP) mouse model of Alzheimer's Disease (AD). TLT was administered 3 times/week at escalating doses, starting at 3 months of age, and was compared to a control group which received no laser treatment. Treatment sessions were continued for a total of six months. The brains were examined for amyloid plaque burden, Aβ peptides (Aβ_1-40 and Aβ_1-42 ), APP cleavage products (sAPPα, CTFβ) and mitochondrial activity. Administration of TLT was associated with a significant, dose-dependent reduction in amyloid load as indicated by the numbers of Aβ plaques. Levels of Aβ_1-40 and Aβ_1-42 levels were likewise reduced in a dose-dependent fashion. All TLT doses produced an increase in brain sAPPα and a decrease in CTFβ levels consistent with an increase in α-secretase activity and a decrease in β-secretase activity. In addition, TLT increased ATP levels and oxygen utilization in treated animals suggesting improved mitochondrial function. These studies suggest that TLT is a potential candidate for treatment of AD.

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Thomas McCarthy, Jin Yu, Salim El-Amouri, Sebastiano Gattoni-Celli, Steve Richieri, Luis De Taboada, Jackson Streeter, and Mark S. Kindy "Transcranial laser therapy alters amyloid precursor protein processing and improves mitochondrial function in a mouse model of Alzheimer's disease", Proc. SPIE 7887, Mechanisms for Low-Light Therapy VI, 78870K (17 February 2011); https://doi.org/10.1117/12.877028

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