With the improvement of living standard, the incidence of diabetes increases year by year. Minimally invasive blood
glucose monitoring is an effectively way to control diabetes, and it is achieved by measuring the glucose concentration of
interstitial fluid in human body. This paper presents a portable minimally-invasive human glucose detection instrument
which is based on a miniature integrated surface plasmon resonance (SPR) sensor. D-galactose/D-glucose Binding
Protein (GGBP) which can specifically absorb glucose moleculars is used to modify the gold surface of SPR sensor for
higher sensitivity and stability. The instrument includes an interstitial fluid extraction unit, a liquid flow unit, a SPR
sensor unit and a circuit control unit. Interstitial fluid is extracted from human body using the interstitial fluid extraction
unit, and it is then transported to the SPR sensor by the liquid flow unit, and the SPR sensor can detect the glucose
concentration in the interstitial fluid. The acquisition and process of data is controlled by the circuit control unit, which
controls the operation of the whole system as well. The glucose detection resolution could reach 6.25mg/L, and the
experiment result has good linearity when the glucose concentration ranges from 6.25mg/L to 50mg/L.
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