Effectiveness in total reduction of Candida albicans promoted by PDT with hypocrellin B:lanthanum

Daniel J. Tofolli; Renato A. Prates; Martha S. Ribeiro; Nilson D. Vieira Jr.; M. C. E. Hashimoto; Lilia C. Courrol

doi:10.1117/12.823013

13 July 2009 Effectiveness in total reduction of Candida albicans promoted by PDT with hypocrellin B:lanthanum

Daniel J. Tofolli, Renato A. Prates, Martha S. Ribeiro, Nilson D. Vieira Jr., M. C. E. Hashimoto, Lilia C. Courrol

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 738060 (2009) https://doi.org/10.1117/12.823013
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

In this work we described the potentiality of the Hypocrellin B (HB) modified with the presence of lanthanum (La³⁺) ions, in eliminate Candida albicans in suspension. The results showed that the presence of lanthanum ions promotes a red shift of the HB absorption band and an enhancement in singlet oxygen quantum yield in 32%. Also in this work we obtained that the best molar ration between HB and La concentrations was 1:2. No photobleaching was observed in our experimental conditions. Antimicrobial activity was studied exciting C. albicans suspension with a 460 nm LED and a 660 nm laser both with 330 mW/cm² irradiance. Best irradiation time, PS concentration and ROS production profile were determined showing that using 460 nm LED with 10 μM of PS, only 30 s of irradiation time was sufficient to reduce 100 % C. albicans colonies.

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Daniel J. Tofolli, Renato A. Prates, Martha S. Ribeiro, Nilson D. Vieira Jr., M. C. E. Hashimoto, and Lilia C. Courrol "Effectiveness in total reduction of Candida albicans promoted by PDT with hypocrellin B:lanthanum", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738060 (13 July 2009); https://doi.org/10.1117/12.823013

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