Improvement of up-converting phosphor technology-based biosensor

Chengke Xie; Lihua Huang; Youbao Zhang; Xiaoxian Guo; Jianfeng Qu; Huijie Huang

doi:10.1117/12.805654

27 January 2009 Improvement of up-converting phosphor technology-based biosensor

Chengke Xie, Lihua Huang, Youbao Zhang, Xiaoxian Guo, Jianfeng Qu, Huijie Huang

Proceedings Volume 7156, 2008 International Conference on Optical Instruments and Technology: Optical Systems and Optoelectronic Instruments; 71561H (2009) https://doi.org/10.1117/12.805654
Event: International Conference of Optical Instrument and Technology, 2008, Beijing, China

Abstract

A novel biosensor based on up-converting phosphor technology (UPT) was developed several years ago. It is a kind of optical biosensor using up-converting phosphor (UCP) particles as the biological marker. From then on, some improvements have been made for this UPT-based biosensor. The primary aspects of the improvement lie in the control system. On one hand, the hardware of the control system has been optimized, including replacing two single chip microcomputers (SCM) with only one, the optimal design of the keyboard interface circuit and the liquid crystal module (LCM) control circuit et al.. These result in lower power consumption and higher reliability. On the other hand, a novel signal processing algorithm is proposed in this paper, which can improve the automation and operating simplicity of the UPT-based biosensor. It has proved to have high sensitivity (~ng/ml), high stability and good repeatability (CV<5%), which is better than the former system. It can meet the need of some various applications such as rapid immunoassay, chemical and biological detection and so on.

Citation Download Citation

Chengke Xie, Lihua Huang, Youbao Zhang, Xiaoxian Guo, Jianfeng Qu, and Huijie Huang "Improvement of up-converting phosphor technology-based biosensor", Proc. SPIE 7156, 2008 International Conference on Optical Instruments and Technology: Optical Systems and Optoelectronic Instruments, 71561H (27 January 2009); https://doi.org/10.1117/12.805654

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