Deformability of mice erythrocytes measured by oscillatory optical tweezers

Yu-Shan Huang; Chia-lun Yeh; Guan-Bo Liao; Yi-Fan Chen; Ting-Fen Tsai; Arthur Chiou

doi:10.1117/12.794690

29 August 2008 Deformability of mice erythrocytes measured by oscillatory optical tweezers

Yu-Shan Huang, Chia-lun Yeh, Guan-Bo Liao, Yi-Fan Chen, Ting-Fen Tsai, Arthur Chiou

Author Affiliations +

Proceedings Volume 7038, Optical Trapping and Optical Micromanipulation V; 703809 (2008) https://doi.org/10.1117/12.794690
Event: NanoScience + Engineering, 2008, San Diego, California, United States

Abstract

We used one-dimensional oscillatory optical tweezers in a discrete scanning (or jumping) mode to trap and stretch individual mice erythrocytes and measured their deformation as a function of the jumping distance of the oscillatory trapping beam. In general, we observed that the length of the long axis of red blood cells (RBCs) decreased slightly at small jumping distance and then increased after the jumping distance exceeded a threshold value on the order of a few microns, which is consistent with a recent theoretical prediction. The deformability of three types of mice RBCs, namely the wide-type mice (serving as the control group), old mice, and gene knockout mice were measured and compared. Statistical analysis of their deformability reveals that the RBCs of old mice can be distinguished from those of knockout mice even though these two types of mice exhibit many similar aging-like features.

Citation Download Citation

Yu-Shan Huang, Chia-lun Yeh, Guan-Bo Liao, Yi-Fan Chen, Ting-Fen Tsai, and Arthur Chiou "Deformability of mice erythrocytes measured by oscillatory optical tweezers", Proc. SPIE 7038, Optical Trapping and Optical Micromanipulation V, 703809 (29 August 2008); https://doi.org/10.1117/12.794690

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