Ordered k-space acquisition in contrast enhanced magnetic resonance angiography (CE-MRA)

B. Wu; J. R. Maclaren; R. P. Millane; R. Watts; P. J. Bones

doi:10.1117/12.769429

18 March 2008 Ordered k-space acquisition in contrast enhanced magnetic resonance angiography (CE-MRA)

B. Wu, J. R. Maclaren, R. P. Millane, R. Watts, P. J. Bones

Author Affiliations +

Proceedings Volume 6913, Medical Imaging 2008: Physics of Medical Imaging; 691346 (2008) https://doi.org/10.1117/12.769429
Event: Medical Imaging, 2008, San Diego, California, United States

Abstract

A new way of performing contrast enhanced magnetic resonance angiography (CE-MRA) is presented, in which the entire k-space is decomposed into interlaced subsets that are acquired sequentially. Based on a new parallel imaging technique, Generalized Unaliasing Incorporating object Support constraint and sensitivity Encoding (GUISE), reconstructions can be made using different subsets of k-space to reveal the level of contrast agent in the corresponding data acquisition time period. A proof-of-concept study using a custom made phantom was carried out to examine the utility of the new method. A quantity of contrast agent (copper sulfate solution) was injected into water flowing within a tube while data was acquired using an 8-coil receiver and the modified MRI sequence. A sequence of images was successfully reconstructed at high temporal resolution. This eliminated the need to precisely synchronize data acquisition with contrast arrival. Furthermore, subtraction of a pre-contrast data set prior to reconstruction, which eliminates the need for recovering the static background signal, has proven to be an effective way to improve the SNR and allow a higher temporal resolution to be achieved in recovering the dynamic signal containing contrast level change. Acceptably good reconstruction results were obtained at a temporal resolution equivalent to a 16-fold speed up compared to the time taken to fully sample k-space.

Citation Download Citation

B. Wu, J. R. Maclaren, R. P. Millane, R. Watts, and P. J. Bones "Ordered k-space acquisition in contrast enhanced magnetic resonance angiography (CE-MRA)", Proc. SPIE 6913, Medical Imaging 2008: Physics of Medical Imaging, 691346 (18 March 2008); https://doi.org/10.1117/12.769429

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