Noisy unmaskers of multistability of periodic rhythms in a model of the ventricular cardiac action potential

Elena Surovyatkina; Roman Egorchenkov; Guennady Ivanov

doi:10.1117/12.724609

15 June 2007 Noisy unmaskers of multistability of periodic rhythms in a model of the ventricular cardiac action potential

Elena Surovyatkina, Roman Egorchenkov, Guennady Ivanov

Author Affiliations +

Proceedings Volume 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems; 660211 (2007) https://doi.org/10.1117/12.724609
Event: SPIE Fourth International Symposium on Fluctuations and Noise, 2007, Florence, Italy

Abstract

The coexistence of different dynamical regimes of cardiac cell-model at a fixed set of stimulation parameters, i.e. multistability, revealed by noise is presented in this paper. Numerical simulations are performed using Luo-Rudy (LR1) action potential model. Numerical experiments with LR1 model conducted via noisy periodical stimulation showed the coexistence of several periodic rhythms. Weak noise in period of stimulation causes a hopping process between all the (meta-) stable rhythms of cell-model. This process is reflected in several parallel branches of the bifurcation diagram: noise unveils new, invisible before, stable rhythms which could appear in this model at different initial conditions. The phenomenon of multistability is directly evidenced by other numerical experiments: we have established the multistability property of a cell consisting in the fact that different initial conditions of stimulation (different extrasystole application times) lead to different stable periodic rhythms. We have obtained the shaping of attraction basins on the action potential curves. Such basins of attraction contain a set of initial conditions which determinate a stable periodic rhythm. We have found a close association between the attraction basins of the complex rhythms on the curves of action potential and the cardiac vulnerable windows on ECG record, during which extra stimuli can induce life threatening arrhythmias. Obtained results allow us to make a conclusion that multistability is very important for the electrical conduction system of the heart from the cell level to the integrated function of the heart.

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Elena Surovyatkina, Roman Egorchenkov, and Guennady Ivanov "Noisy unmaskers of multistability of periodic rhythms in a model of the ventricular cardiac action potential", Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 660211 (15 June 2007); https://doi.org/10.1117/12.724609

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KEYWORDS

Action potentials

Avalanche photodetectors

Potassium

Heart

Photonic integrated circuits

Calcium

Electrocardiography

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