Microscopic x-ray imaging system for biomedical applications using synchrotron radiation

Keiji Umetani; Makito Kobatake; Akira Yamamoto; Takenori Yamashita; Shigeki Imai

doi:10.1117/12.702426

21 February 2007 Microscopic x-ray imaging system for biomedical applications using synchrotron radiation

Keiji Umetani, Makito Kobatake, Akira Yamamoto, Takenori Yamashita, Shigeki Imai

Proceedings Volume 6501, Sensors, Cameras, and Systems for Scientific/Industrial Applications VIII; 650112 (2007) https://doi.org/10.1117/12.702426
Event: Electronic Imaging 2007, 2007, San Jose, CA, United States

Abstract

An X-ray direct-conversion type detector with a spatial resolution of 10-11 &mgr;m was developed for real-time biomedical imaging. The detector incorporates the X-ray SATICON pickup tube with a photoconductive target layer of amorphous selenium. For high-resolution imaging, the X-ray image is directly converted into an electric signal in the photoconductive layer without image blur. Microangiography experiments were carried out for depicting angiogenic vessels in a rabbit model of cancer using the direct-conversion detector and a third generation synchrotron radiation source at SPring-8. In synchrotron radiation radiography, a long source-to-object distance and a small source spot can produce high-resolution images. After transplantation of cancer cells into the rabbit auricle, small tumor blood vessels with diameters of 20-30 &mgr;m in an immature vascular network produced by angiogenesis were visualized by contrast material injection into the auricular artery at a monochromatic X-ray energy of 33.2 keV just above the iodine K-edge energy. The synchrotron radiation system is a useful tool to evaluate the micro-angioarchitecture of malignant tumors in animal models of cancer for in vivo preclinical studies.

Citation Download Citation

Keiji Umetani, Makito Kobatake, Akira Yamamoto, Takenori Yamashita, and Shigeki Imai "Microscopic x-ray imaging system for biomedical applications using synchrotron radiation", Proc. SPIE 6501, Sensors, Cameras, and Systems for Scientific/Industrial Applications VIII, 650112 (21 February 2007); https://doi.org/10.1117/12.702426

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KEYWORDS

X-rays

Tumors

X-ray imaging

Sensors

Blood vessels

Imaging systems

Synchrotron radiation

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