Iron oxide nanoparticles as drug delivery agents in MIA PaCa-2 pancreatic cells

Christopher Perry; Alexandrine Randriamahefa; Carl Lokko; Whitney Evans; Julian Watkins; Holly Carrell; Natalie King; Darayas Patel

doi:10.1117/12.701754

19 February 2007 Iron oxide nanoparticles as drug delivery agents in MIA PaCa-2 pancreatic cells

Christopher Perry, Alexandrine Randriamahefa, Carl Lokko, Whitney Evans, Julian Watkins, Holly Carrell, Natalie King, Darayas Patel

Author Affiliations +

Proceedings Volume 6441, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V; 64411T (2007) https://doi.org/10.1117/12.701754
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Oleic acid (OA)-Pluronic-coated iron oxide nanoparticles were synthesized and characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and Atomic Force Microscopy (AFM). FT-IR confirmed the bonding of oleic acid and Pluronic (surfactant) to the nanoparticles. AFM measurements on these nanoparticles indicated a root mean square (RMS) roughness, a measure of nanoparticle size of (50 ± 20) nm. The efficiency of these functionalized nanoparticles was investigated by loading with 5-Fluorouracil (5-FU) in aqueous solution. AFM measurements were used to characterize modified iron oxide nanoparticles and pancreatic MIA PaCa-2 cells, including size distribution, stability and cellular uptake. Nanoparticles were added to MIA PaCa-2 cells and assayed for their cytotoxic effects after 24 and 48 hours. The outcome of this study demonstrated the effectiveness of oleic acid (OA)-Pluronic-coated iron oxide nanoparticles as a non-toxic drug delivery agent for pancreatic cancer.

Citation Download Citation

Christopher Perry, Alexandrine Randriamahefa, Carl Lokko, Whitney Evans, Julian Watkins, Holly Carrell, Natalie King, and Darayas Patel "Iron oxide nanoparticles as drug delivery agents in MIA PaCa-2 pancreatic cells", Proc. SPIE 6441, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues V, 64411T (19 February 2007); https://doi.org/10.1117/12.701754

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