Dynamics of morphofunctional erythrocyte properties during intravenous glucose injection in patients with coronary heart disease

Lidia I. Malinova; Georgy V. Simonenko; Tatyana P. Denisova; Valery V. Tuchin

doi:10.1117/12.712727

8 February 2007 Dynamics of morphofunctional erythrocyte properties during intravenous glucose injection in patients with coronary heart disease

Lidia I. Malinova, Georgy V. Simonenko, Tatyana P. Denisova, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV; 64360U (2007) https://doi.org/10.1117/12.712727
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Dynamics of glucose concentration in human organism is an important diagnostic characteristic for it's parameters correlate significantly with the severity of metabolic, vessel and perfusion disorders. 36 patients with stable angina pectoris of II and III functional classes were involved in this study. All of them were men in age range of 45-59 years old. 7 patients hospitalized with acute myocardial infarction (aged from 49 to 59 years old) form the group of compare. Control group (n = 5) was of practically healthy men in comparable age. To all patients intravenous glucose solution (40%) in standard loading dose was injected. Capillary and vein blood samples were withdrawn before, and 5, 60, 120, 180 and 240 minutes after glucose load. At these time points blood pressure and glucose concentration were measured. In prepared blood smears shape, deformability and sizes of erythrocytes, quantity and degree of shear stress resistant erythrocyte aggregates were studied. Received data were approximated by polynomial of high degree to receive concentration function of studied parameters, which first derivative elucidate velocity characteristics of morphofunctional erythrocyte properties during intravenous glucose injection in patients with coronary heart disease and practically healthy persons. Received data show principle differences in dynamics of morphofunctional erythrocyte properties during intravenous glucose injection in patients with coronary heart disease as a possible mechanism of coronary blood flow destabilization.

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Lidia I. Malinova, Georgy V. Simonenko, Tatyana P. Denisova, and Valery V. Tuchin "Dynamics of morphofunctional erythrocyte properties during intravenous glucose injection in patients with coronary heart disease", Proc. SPIE 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV, 64360U (8 February 2007); https://doi.org/10.1117/12.712727

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KEYWORDS

Glucose

Heart

Blood

Organisms

Directed energy weapons

Blood circulation

Statistical analysis

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