Molecular and structural preservation of dehydrated bio-tissue for THz spectroscopy

Gretel M. Png; Jin Wook Choi; Ian Guest; Brian W.-H. Ng; Samuel P. Mickan; Derek Abbott; Xi-Cheng Zhang

doi:10.1117/12.695767

14 December 2006 Molecular and structural preservation of dehydrated bio-tissue for THz spectroscopy

Gretel M. Png, Jin Wook Choi, Ian Guest, Brian W.-H. Ng, Samuel P. Mickan, Derek Abbott, Xi-Cheng Zhang

Proceedings Volume 6416, Biomedical Applications of Micro- and Nanoengineering III; 64160W (2006) https://doi.org/10.1117/12.695767
Event: SPIE Smart Materials, Nano- and Micro-Smart Systems, 2006, Adelaide, Australia

Abstract

Terahertz transmission through freshly excised biological tissue is limited by the tissue's high water content. Tissue fixation methods that remove water, such as fixation in Formalin, destroy the structural information of proteins hence are not suitable for THz applications. Dehydration is one possible method for revealing the tissue's underlying molecular structure and components. In this study, we measured the THz responses over time of dehydrating fresh, necrotic and lyophilized rat tissue. Our results show that as expected, THz absorption increases dramatically with drying and tissue freshness can be maintained through lyophilization. Dehydrated biological tissue with retained molecular structure can be useful for future laser-based THz wave molecular analysis.

Citation Download Citation

Gretel M. Png, Jin Wook Choi, Ian Guest, Brian W.-H. Ng, Samuel P. Mickan, Derek Abbott, and Xi-Cheng Zhang "Molecular and structural preservation of dehydrated bio-tissue for THz spectroscopy", Proc. SPIE 6416, Biomedical Applications of Micro- and Nanoengineering III, 64160W (14 December 2006); https://doi.org/10.1117/12.695767

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available