Resonant effects in a voltage-activated channel gating

Ewa Gudowska-Nowak; Bartlomiej Dybiec; Henrik Flyvbjerg

doi:10.1117/12.548556

25 May 2004 Resonant effects in a voltage-activated channel gating

Ewa Gudowska-Nowak, Bartlomiej Dybiec, Henrik Flyvbjerg

Proceedings Volume 5467, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems II; (2004) https://doi.org/10.1117/12.548556
Event: Second International Symposium on Fluctuations and Noise, 2004, Maspalomas, Gran Canaria Island, Spain

Abstract

The non-selective voltage activated cation channel from the human red cells, which is activated at depolarizing potentials, has been shown to exhibit counter-clockwise gating hysteresis. We have analyzed the phenomenon with the simplest possible phenomenological models by assuming 2×2 discrete states, i.e. two normal open/closed states with two different states of "gate tension." Rates of transitions between the two branches of the hysteresis curve have been modeled with single-barrier kinetics by introducing a real-valued "reaction coordinate" parameterizing the protein's conformational change. When described in terms of the effective potential with cyclic variations of the control parameter (an activating voltage), this model exhibits typical "resonant effects": synchronization, resonant activation and stochastic resonance. Occurrence of the phenomena is investigated by running the stochastic dynamics of the model and analyzing statistical properties of gating trajectories.

Citation Download Citation

Ewa Gudowska-Nowak, Bartlomiej Dybiec, and Henrik Flyvbjerg "Resonant effects in a voltage-activated channel gating", Proc. SPIE 5467, Fluctuations and Noise in Biological, Biophysical, and Biomedical Systems II, (25 May 2004); https://doi.org/10.1117/12.548556

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