Flexible coupling of a waveguide detector with a microscale field flow fractionation device

Himanshu J. Sant; Bruce K. Gale

doi:10.1117/12.529377

23 December 2003 Flexible coupling of a waveguide detector with a microscale field flow fractionation device

Himanshu J. Sant, Bruce K. Gale

Author Affiliations +

Proceedings Volume 5345, Microfluidics, BioMEMS, and Medical Microsystems II; (2003) https://doi.org/10.1117/12.529377
Event: Micromachining and Microfabrication, 2004, San Jose, California, United States

Abstract

This paper describes a simple packaging method to fabricate microfluidic channels and obtain an optical detection interface for micro analysis systems. Specifically, this work reports on efforts to develop new methods for simple, fast and reliable design and fabrication of microscale field flow fractionation (FFF) based biological analysis systems. This modular detector interface results in a 38 nl detection region. Detector characterization is carried out to evaluate important figures of merit such as sensitivity, S/N ratio, and limit of detection. Plate height, a primary performance criterion for field flow fractionation is determined and compared with an on-chip detector. The developed system allow for a plug-and-play approach to the optical interface has resulted in flexibility in operation and increased robustness of the micro device.

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Himanshu J. Sant and Bruce K. Gale "Flexible coupling of a waveguide detector with a microscale field flow fractionation device", Proc. SPIE 5345, Microfluidics, BioMEMS, and Medical Microsystems II, (23 December 2003); https://doi.org/10.1117/12.529377

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