Novel near-infrared nanoparticlulate biomarker: preparation and stability studies

Vishal Saxena; Mostafa Sadoqi; Sunil Kumar; Jun Shao

doi:10.1117/12.534317

14 June 2004 Novel near-infrared nanoparticlulate biomarker: preparation and stability studies

Vishal Saxena, Mostafa Sadoqi, Sunil Kumar, Jun Shao

Proceedings Volume 5329, Genetically Engineered and Optical Probes for Biomedical Applications II; (2004) https://doi.org/10.1117/12.534317
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Degradation of Indocyanine green (ICG) in aqueous media, limits its application in early tumor diagnosis and therapy. Thus, the objective of this study is to develop biodegradable nanoparticles entrapping ICG and to establish its effectiveness in providing overall stability to ICG. Nanoparticles entrapping ICG were engineered and characterized. The degradation kinetics of ICG in the nanoparticles was investigated in aqueous media. The degradation of ICG in aqueous nanoparticle suspension followed first-order kinetics. Nanoparticles enhanced aqueous, photo and thermal-stability of ICG.

Citation Download Citation

Vishal Saxena, Mostafa Sadoqi, Sunil Kumar, and Jun Shao "Novel near-infrared nanoparticlulate biomarker: preparation and stability studies", Proc. SPIE 5329, Genetically Engineered and Optical Probes for Biomedical Applications II, (14 June 2004); https://doi.org/10.1117/12.534317

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