Photoacoustic diagnosis of burns in rats: two-dimensional photoacoustic imaging of burned tissue

Mutsuo Yamazaki; Shunichi Sato; Daizo Saito; Yoshiaki Okada; Akira Kurita; Makoto Kikuchi; Hiroshi Ashida; Minoru Obara

doi:10.1117/12.477638

1 July 2003 Photoacoustic diagnosis of burns in rats: two-dimensional photo-acoustic imaging of burned tissue

Mutsuo Yamazaki, Shunichi Sato, Daizo Saito, Yoshiaki Okada, Akira Kurita, Makoto Kikuchi, Hiroshi Ashida, Minoru Obara

Proceedings Volume 4960, Biomedical Optoacoustics IV; (2003) https://doi.org/10.1117/12.477638
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

We previously reported that for rat burn models, deep dermal burns and deep burns can be well differentiated by measuring the propagation time of the photoacoustic signals originated from the blood in the healthy skin tissue under the damaged tissue layer. However, the diagnosis was based on point measurement in the wound, and therefore site-dependent information on the injuries was not obtained; such information is very important for diagnosis of extended burns. In the present study, we scanned a photoacoustic detector on the wound and constructed two-dimensional (2-D) images of the blood-originated photoacoustic signals for superficial dermal burns (SDB), deep dermal burns (DDB), deep burns (DB), and healthy skins (control) in rats. For each burn model, site-dependent variation of the signal was observed; the variation probably reflects the distribution of blood vessels in the skin tissue. In spite of the variation, clear differentiation was obtained between SDB, DDB, and DB from the 2D images. The images were constructed as a function of post burn time. Temporal signal variation will be also presented.

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Mutsuo Yamazaki, Shunichi Sato, Daizo Saito, Yoshiaki Okada, Akira Kurita, Makoto Kikuchi, Hiroshi Ashida, and Minoru Obara "Photoacoustic diagnosis of burns in rats: two-dimensional photo-acoustic imaging of burned tissue", Proc. SPIE 4960, Biomedical Optoacoustics IV, (1 July 2003); https://doi.org/10.1117/12.477638

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