Detection of glaucomatous retinal nerve fiber layer damage by scanning laser polarimetry with variable corneal compensation

Qienyuan Zhou; Jerry Reed; Ryan W. Betts; Peter Karl Trost; Pak-Wai Lo; Charles Wallace; Richard H. Bienias; Guoqiang Li; Ross Winnick; William A. Papworth; Michael Sinai

doi:10.1117/12.477975

14 July 2003 Detection of glaucomatous retinal nerve fiber layer damage by scanning laser polarimetry with variable corneal compensation

Qienyuan Zhou, Jerry Reed, Ryan W. Betts, Peter Karl Trost, Pak-Wai Lo, Charles Wallace, Richard H. Bienias, Guoqiang Li, Ross Winnick, William A. Papworth, Michael Sinai

Author Affiliations +

Proceedings Volume 4951, Ophthalmic Technologies XIII; (2003) https://doi.org/10.1117/12.477975
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

One of the earliest signs of glaucoma presence is defects in the retinal nerve fiber layer (RNFL). Scanning laser polarimetry (SLP) provides objective assessment of RNFL, a birefringent tissue, by measuring the total retardation in the reflected light. SLP provides a potential tool for early detection of glaucoma and its progression. The birefringence of the anterior segment of the eye, mainly the cornea, is a confounding variable to SLP's clinical application, if compensation cannot be achieved properly. This paper presents a new SLP system, GDx VCC (Laser Diagnostic Technologies, Inc., San Diego, CA), with a variable corneal compensator (VCC) to achieve individualized corneal compensation. Clinical application of this device in glaucoma detection is also demonstrated.

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Qienyuan Zhou, Jerry Reed, Ryan W. Betts, Peter Karl Trost, Pak-Wai Lo, Charles Wallace, Richard H. Bienias, Guoqiang Li, Ross Winnick, William A. Papworth, and Michael Sinai "Detection of glaucomatous retinal nerve fiber layer damage by scanning laser polarimetry with variable corneal compensation", Proc. SPIE 4951, Ophthalmic Technologies XIII, (14 July 2003); https://doi.org/10.1117/12.477975

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