Effects of in-vitro target compression modulus on laser thrombolytic ablation rate

Abram D. Janis; Sean J. Kirkpatrick; Kenton W. Gregory M.D.; Scott A. Prahl

doi:10.1117/12.441250

17 June 2002 Effects of in-vitro target compression modulus on laser thrombolytic ablation rate

Abram D. Janis, Sean J. Kirkpatrick, Kenton W. Gregory M.D., Scott A. Prahl

Proceedings Volume 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII; (2002) https://doi.org/10.1117/12.441250
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Laser thrombolysis is under investigation as a safe and rapid therapy for arterial recanalization in acute embolic stroke. Clot formation is a complex process affected by many factors that lead to differences in strength and hemoglobin concentration in samples formed from whole blood. The strength of thrombus formed in vivo also varies with age. Laser thrombolysis experiments were performed using a 577 nm 1 sec pulsed dye laser at an energy of approximately 25 mJ and a repetition rate of 4 Hz. Laser ablation and confined compression modulus were measured with three in vitro clot models: gelatin, static clot, and reconstituted clot. Laser ablation studies demonstrate that laser ablation efficiency (µg/mJ/pulse) is not significantly affected by differences in the confined compression modulus of clot. This agrees with previous studies using dye and gelatin. These results provide support for the effective use of this laser thrombolysis system for the removal of clots of varied age and strength.

Citation Download Citation

Abram D. Janis, Sean J. Kirkpatrick, Kenton W. Gregory M.D., and Scott A. Prahl "Effects of in-vitro target compression modulus on laser thrombolytic ablation rate", Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); https://doi.org/10.1117/12.441250

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