Raman background photobleaching as a possible method of cancer diagnostics

Nikolai N. Brandt; Andrey Yuri Chikishev; Mihail G. Gangardt; Nina F. Karyakina

doi:10.1117/12.429339

13 June 2001 Raman background photobleaching as a possible method of cancer diagnostics

Nikolai N. Brandt, Andrey Yuri Chikishev, Mihail G. Gangardt, Nina F. Karyakina

Proceedings Volume 4263, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring; (2001) https://doi.org/10.1117/12.429339
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Kinetics of photobleaching of background in Raman spectra of aqueous solutions of plant toxins ricin and ricin agglutinin, ricin binding subunit, and normal and malignant human blood serum were measured. For the excitation of the spectra cw and pulsed laser radiation were used. The spectra of Raman background change upon laser irradiation. Background intensity is lower for the samples with small molecular weight. The cyclization of amino acid residues in the toxin molecules as well as in human blood serum can be a reason of the Raman background. The model of the background photobleaching is proposed. The differences in photobleaching kinetics in the cases of cw and pulsed laser radiation are discussed. It is shown that Raman background photobleaching can be very informative for cancer diagnostics.

Citation Download Citation

Nikolai N. Brandt, Andrey Yuri Chikishev, Mihail G. Gangardt, and Nina F. Karyakina "Raman background photobleaching as a possible method of cancer diagnostics", Proc. SPIE 4263, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring, (13 June 2001); https://doi.org/10.1117/12.429339

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