Maximum tolerable dose (MTD): a new index for ultraviolet radiation toxicity in the lens

Per G. Soderberg; Stefan Lofgren; Marcelo Ayala; M. Kakar

doi:10.1117/12.429275

7 June 2001 Maximum tolerable dose (MTD): a new index for ultraviolet radiation toxicity in the lens

Per G. Soderberg, Stefan Lofgren, Marcelo Ayala, M. Kakar

Author Affiliations +

Proceedings Volume 4245, Ophthalmic Technologies XI; (2001) https://doi.org/10.1117/12.429275
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The maximum tolerable dose (MTD2.3:16) for avoidance of cataract on exposure to UVR-300 nm in the rat was currently estimated to 3.65 kJ/m². For this, Sprague-Dawley rats were unilaterally exposed to UVR in the 300 nm wavelength region, generated with a high pressure mercury arc source. The intensity of forward light scattering was measured one week after exposure. MTD allows estimation of toxicity for continuous response events with small sample experiments. Current safety standards for avoidance of cataract after exposure to UVR are based on a binary response event. It has however recently been shown that UVR-induced cataract is a continuous dose-dependent event. MTD provides a statistically well defined criterium of toxicity for continuous response events.

Citation Download Citation

Per G. Soderberg, Stefan Lofgren, Marcelo Ayala, and M. Kakar "Maximum tolerable dose (MTD): a new index for ultraviolet radiation toxicity in the lens", Proc. SPIE 4245, Ophthalmic Technologies XI, (7 June 2001); https://doi.org/10.1117/12.429275

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